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Do I have to lay down after Progesterone suppositories? Your body will have already absorbed what it's needed to. I've taken them before and they get messy so make sure to start out wearing a panty liner. I insert them at the toilet like a tampon. They don't fall out, so you don't need to worry about that.
Can progesterone interfere with sleep? Progesterone increases production of GABA, a neurotransmitter that helps sleep. Low progesterone can bring about anxiety and restlessness, and trouble sleeping, including a tendency to wake frequently during the night.
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